Right after Shrek and Princess Fiona's honeymoon, the newly wed couple goes to Princess Fiona's parents for dinner. When a Fairy Godmother discovers Fiona and Shrek are married she reminds the king about a deal they areed on years ago, that Fiona should have married her son, who happens to be Prince Charming. The King then hires a cat named Puss-in-Boots, a sword fighting cat and ogre slayer, to kill Shrek.

Struggling songwriter Dave Seville opens his home to a talented trio of chipmunks named Alvin, Simon, and Theodore. When they become overnight music sensations, a greedy record producer tries to exploit the 'boys.' Now Dave must use a little human ingenuity and a lot of 'munk mischief to get his furry family back before it's too late.