Lifelong buddies Willie, Joe, and Al decide to buck retirement and step off the straight and narrow for the first time in their lives when their pension fund becomes a corporate casualty. To pay the bills and come through for their loved ones, the three risk it all by embarking on a daring bid to knock off the very bank that absconded with their money.

As the Best Exotic Marigold Hotel has only a single remaining vacancy - posing a rooming predicament for two fresh arrivals - Sonny pursues his expansionist dream of opening a second hotel.

Long-term couple John and Ella Robina are experiencing the struggles of growing older. With John having Alzheimer's and Ella undergoing cancer treatment, they decide to abandon their disease-stricken lifestyles and embark on a journey from Boston to Key West in an attempt to fully live what's left of their lives. Their trusty RV, which they've dubbed "The Leisure Seeker", will be their mode of transportation as they enjoy what may be their last adventure...