Struggling songwriter Dave Seville opens his home to a talented trio of chipmunks named Alvin, Simon, and Theodore. When they become overnight music sensations, a greedy record producer tries to exploit the 'boys.' Now Dave must use a little human ingenuity and a lot of 'munk mischief to get his furry family back before it's too late.

After Dave has an accident at one of their concerts, chipmunks Alvin, Simon, and Theodore take a break from stardom and enroll in a public school where they attempt to fit in with other kids their own age, but a trio of female chipmunks, the Chipettes, give them serious competition.